Sildenafil Mechanism: All You Need to Know About Sildenafil

Sildenafil is the primary pharmaceutical ingredient used for the treatment of Erectile Dysfunction (otherwise known as impotence) and Pulmonary Hypertension. This chemical agent is famous on the internet as a major component of most generic brands for impotence treatment.

Viagra is the first Sildenafil impotence treatment; this drug was developed by Pfizer, which is the same company that owns Revatio, the brand drug for pulmonary hypertension. Viagra comes as diamond-shaped film-coated tablets presented in three tablet strengths which are 25Mg, 50Mg, and 100Mg.

Sildenafil Generic Products

The little blue pills are designed for men who have difficulties in responding accordingly to sexual stimulation. These are the male adults who find it hard to generate an erection or to maintain a viable one to see them through the intercourse.

Viagra has several generic counterparts in the market which come in different shapes and colors. Some famous brand names for generic Viagra are Suhagra, Fildena, Silagra, Vigora, and Kamagra. These generic Sildenafil Citrate brands, unlike Viagra, come in more exciting forms and flavors.

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Kamagra oral jelly

Interestingly, some Sildenafil remedies exist that are made for women use, such as the “Female Viagra” used to increase the sexual performance of the women. This type of Viagra resembles the ordinary Sildenafil tablet; the only difference is its pink color. Scientific research has yet to illustrate the reason why some Sildenafil products are used in isolation by distinct sexes. Nonetheless, Sildenafil function across products is similar in the body despite the differences in manufacturer and intended use for the product.

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Female Viagra


Besides the male and female generic Sildenafil tablets, there are also Sildenafil Citrate products with more than one pharmaceutical ingredient. An example is Sildigra Super Power, which contains 100mg of Sildenafil and 60mg of Dapoxetine. It is appropriate for patients with severe impotence unresponsive to the conventional Sildenafil medications.

Sildenafil Uses and Mechanism of Action

Sildenafil is often bought in packs of four tablets with each bearing 25 mg, 50 mg or 100 g of the ingredient. In cases of oral jellies, the available quantity is 100 mg sachets in various fruit flavors such as banana, strawberry, and mango, amongst others. Despite the form, one should take oral jellies once daily. A tablet of Sildenafil is to be administered within 24 hours while a sachet is to be treated similarly.

Sildenafil should be consumed once in 24 hours. The tablets should be administered with water while a sachet of the oral jelly is taken with or without water. The medicine should be stored away from heat and moisture out of children’s reach. Taking it on an empty stomach about an hour before the sexual process can help increase Sildenafil efficacy in the body.

Sildenafil is clustered as a Phosphodiesterase 5(PDE-5) inhibitor, and it works by blocking the enzyme Phosphodiesterase from working efficiently. The Enzyme in question is mostly found in the groins where it hardens the soft muscles in the blood vessels to bring about their contractions.

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Image: Blood vessels

As a result of this blockage which is attributed to be the highest cause of impotence, the diameter of the veins is increased allowing more blood into the penile tissues. When the circulation of blood to the erectile organ is improved, a normal arousal process is all that is left to harden the penis ready for the sexual activity. Sildenafil onset is shorter when taken on an empty stomach and much efficient if administered an hour before the procreation. Its effects take an average of four hours in the body.

Who should not be allowed to take Sildenafil?

·         patients who are allergic to Sildenafil

·         patients who consume nitrate-containing medicines

·         males with some terminal health conditions, like patients with kidney, liver, and heart diseases

·         those who have diabetes or with eye problems

Sildenafil Citrate Side Effects

It is wise to follow your doctor’s instructions on how to use the drug as it minimizes the chances of getting adverse outcomes from the consumption. However, at times these side effects are unavoidable despite adhering to the doctor’s script. Some of the common ones in the likes of headaches, facial flushes, fever, Stomach upsets, backaches, vomiting, nausea and muscle cramps decrease with tolerance and subside in a few hours to a few days. However, patients should seek immediate medical help when they experience the following.

  • Priapism- a prolonged erection that lasts for more than four hours and is characterized by pain.
  • Loss of Vision- this might happen as blur vision, color distortions or a sudden loss of sight to one or both eyes.
  • Loss of hearing- One might drastically lose the ability to hear with one ear or both of them as a result of taking Sildenafil.
  • Hypotension- this is the life-threatening levels of low blood pressure which can occur since Sildenafil works by relaxing the blood carrying vessels thus reducing the pressure at which it flows.

These adverse symptoms may lead to permanent deformities or even death without prompt medical attention as soon as they occur when chances of reversing them are at their best. Make sure to have a complete health screen from your medical physician before using Sildenafil.[2]


Sildenafil Citrate is an erectile dysfunction drug publicly known as Viagra from Pfizer. However, apart from Viagra, there are still other Sildenafil Citrate-based products available, such as the generic variants from other renowned generic manufacturers from all over the world. Regardless of brand, Sildenafil works by inhibiting the enzyme PDE5, therefore allowing increased blood flow to the penis, hence the efficient erectile response in the male users of the medicine. Sildenafil Citrate is a good drug to try, but only with the recommendation of the doctors. You can purchase Sildenafil Citrate at your local drugstores, but you can also avail of the drug online, especially at stores included on our list of top online drugstores for the recent year.

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