Raloxifene Vs Tamoxifen: Lifesavers with a Catch

Tamoxifen 20 Mg – What Exactly Does This Drug Do?

Drugs could be a lifesaver and in this case, Raloxifene (Raloxifene Hydrochloride) and Tamoxifen (Tamoxifen Citrate) are two drug compounds that have the potential to save lives, especially those lives that breast cancer, postmenopausal osteoporosis and gynecomastia has sought to destroy or at least to make miserable.

Both Raloxifene and Tamoxifen belong to a class of medications described as Selective Estrogen Receptor Modulators (SERMs), they are described as such because they have the capacity to be estrogen receptor agonists or antagonists depending on the body tissue it acts on, a short analogy of what SERMs do is presented in the following example; when you bath with Soap, it cleanses the body but if you let it in your eyes or nostrils it will cause pain, the idea? Your body and your eyes are two different tissues, soap acts on each differently; it cleanses the body and peppers the eyes.

Raloxifene Vs Tamoxifen Gyno

Gynecomastia, sometimes referred to vaguely as ‘gyno’ describes a clinical condition where a man’s breast is unusually enlarged. Glandular tissues beneath the nipple region tend to grow gradually until a mass looking like a female breast is formed. This condition is not to be mistaken with breast cancer as the lump involved is benign, i.e. non cancerous but could be painful in a few instances, it also shouldn’t be confused with seeming breast enlargement in obese men which is as a result of underlying excess fatty acid. It can occur in a male of any age but usually it starts at the pubertal stage when hormones are generally climbing to a greater level and becoming more expressive, at this point a lot of males experience it but in most individuals (about 90%), the lump starts to wear away following the ‘hormonal high-point’.

Gynecomastia is caused by an imbalance between androgen and estrogen hormones in the male, with estrogen hormones being on the higher side, it could lead to embarrassment or psychological distress in males experiencing it, but then look on the brighter side, there’s a 90% chance that it will wear off in a couple of months. For someone experiencing gynecomastia symptoms, physical examination and careful consideration of medical history is required to determine causal factors and treatment options, as mentioned earlier most pubertal gynecomastia cases resolve themselves naturally, only a select number of cases usually require medication or surgery. In events when pharmacological treatment is required for gynecomastia in an individual, there’s a very high chance of getting a hormone drug prescription, either Tamoxifen or Raloxifene could be prescribed by your doctor as clinical studies have shown that SERMs are effective in treating the condition with Raloxifene enjoying a better response than Tamoxifen, both drugs come in orally administered tablets. Tamoxifen and Raloxifene have not been approved by the FDA specifically for the treatment of gynecomastia but doctors prescribe them off-label as clinical trials have shown them to be effective in the treatment of this condition, medical treatment for gynecomastia is most effective when started within the first two years of symptomatic expressions. See your doctor to know which is better in your case.

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Evista Tablets

Tamoxifen Vs Raloxifene Endometrial Cancer

Endometrial cancer is the cancer that affects the endometrium (the uterus lining), symptoms can include pelvic pain and vaginal bleeding unassociated with menstrual period. Tamoxifen and Raloxifene share a lot in common being members of the same drug class, SERMs; they are instrumental medications in the prevention and treatment of breast cancer in men and women. Both drugs perform an antagonistic function on estrogen receptors in the breast tissue thus giving breast cancer a hard time growing at all. SERMs can be estrogenic or anti-estrogenic depending on the target body tissue, Clinical studies have shown that Tamoxifen is estrogenic in the endometrium while Raloxifene is anti-estrogenic and excessive exposure of the endometrium to estrogen is a high risk cancer factor, other high risk cancer factors include high blood pressure, obesity and diabetes, endometrial cancer is known to occur more in women that are postmenopausal, these studies conclude that those under Raloxifene therapy had a significantly lower odd in having endometrial cancer than those under Tamoxifen therapy.

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Raloxifene Vs Tamoxifen Side Effects

Raloxifene and Tamoxifen share similar side effects but mildness or severeness of side effects varies with each drug. The most common side effects of Raloxifene include headaches, leg cramps, hot flashes, vaginal dryness, painful urination and joint or muscle pain but a side effect of this drug that calls for concern is blood clots. The same common side effects apply to Tamoxifen but side effects of Tamoxifen that call for concern include its potential to cause endometrial cancer, stroke, and blood clots in the lungs. The side effects listed here are not exhaustive, if you experience any sort of discomfort when using either drug, see your doctor immediately.


While Tamoxifen (Nolvadex) is specifically approved by the FDA for the prevention and treatment of breast cancer in both men and women and Raloxifene (Evista) is specifically approved by the FDA for treatment of Osteoporosis (soft and brittle bone) which is commonly experienced by post menopausal women, both drugs have a lot in common; they are both orally administered prescription medications, they belong to the same drug class description- SERMs, they also share certain side effects although intensity of side effects vary with either drug. The information in this piece is not a substitute for medical advice; consult your doctor to know which drug you should use and how to use it. Check out our catalogue of top recommended online pharmacies for the best deals on any drug you want.

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